Biosynthesis of phosphatidic acid from dihydroxyacetone phosphate
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چکیده
منابع مشابه
BIOCHEMICAL AND BlOPHYSlCAL RESEARCH COMMUNICATIONS BIOSYNTHESIS OF PHOSPHATIDIC ACID FROM DIHYDROXYACETONE PHOSPHATE
Phosphatidic acid is synthesized by a particulate preparation of of guinea pig liver from dihydroxyacetone phosphate, acyl CoAs and NADPH via acyl dihydroxyacetone phosphate. Glycerol-3-phosphate is also converted to phosphatidate in this system. The phosphatidate formed via acyl dihydroxyacetone phosphate has more saturated fatty acid in the lposition than in the Z-position, while the fatty ac...
متن کاملBiosynthesis of phosphatidic acid in rat brain via acyl dihydroxyacetone phosphate.
The enzymes for the biosynthesis of phosphatidic acid from acyl dihydroxyacetone phosphate were shown to be present in rat brain. These enzymes were mainly localized in the microsomal fraction of 12--14 day old rat brains. The brain microsomal acyl C0A:dihydroxyacetone phosphate acyl transferase (EC 2.3.1.42). exhibited a broad pH optimum between pH 5 and 9 with maximum activity at pH 5.4. K, f...
متن کاملRedundant systems of phosphatidic acid biosynthesis via acylation of glycerol-3-phosphate or dihydroxyacetone phosphate in the yeast Saccharomyces cerevisiae.
In the yeast Saccharomyces cerevisiae lipid particles harbor two acyltransferases, Gat1p and Slc1p, which catalyze subsequent steps of acylation required for the formation of phosphatidic acid. Both enzymes are also components of the endoplasmic reticulum, but this compartment contains additional acyltransferase(s) involved in the biosynthesis of phosphatidic acid (K. Athenstaedt and G. Daum, J...
متن کاملBiosynthesis of alkyl-ether containing lipid from dihydroxyacetone phosphate.
A lipid, stable to alkaline methanolysis, is formed when liver mitochondria or brain microsomes are incubated with dihydroxyacetone phosphate, long chain alcohol, ATP, CoA, NaF and Mg*. The lipid has been identified as alkyl dihydroxyacetone phosphate. This lipid is reduced by NADPH to 1-alkyl glycerol3-phosphate and is further acylated to form 1-alkyl 2-acyl glycerol-3-phosphate. The ether-con...
متن کاملGlycerolipid biosynthesis in peroxisomes via the acyl dihydroxyacetone phosphate pathway.
In recent years, acyl dihydroxyacetone phosphate [acyl-DHAPt) has been shown to be a precursor of glycerolipids and glycerol-ether lipids.'.' Acyl-DHAP was discovered as a rapidly labeled lipid that was formed in crude mitochondrial fraction from 3'Pi or y-32P[ATP].3 This rapid labeling was due to the enzymatic dephosphorylation and rephosphorylation of endogenous acyl-DHAP present in the crude...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 1968
ISSN: 0006-291X
DOI: 10.1016/0006-291x(68)90401-4